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Of the overall variety of topics consisted of in PLESS, 1480 as well as 105 topics were 65 and over and 75 as well as over, respectively. No total differences in security or efficiency were noted between these subjects and younger topics, and various other reported professional encounter has actually not identified distinctions in feedbacks between the senior and also younger clients. No dose modification is required in the senior [view Clinical Pharmacology (12.3) as well as Clinical Studies (14)]





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Care should be worked out in the administration of Proscar in those patients with liver feature irregularities, as finasteride is metabolized extensively in the liver [see Clinical Pharmacology (12.





Patients have received single dosages of Proscar approximately 400 mg and also a number of dosages of Proscar approximately 80 mg/day for three months without adverse effects. Up until more experience is gotten, no certain treatment for an overdose with Proscar can be suggested.





Considerable lethality was observed in male as well as women computer mice at solitary dental dosages of 1500 mg/m2 (500 mg/kg) as well as in women and male rats at single oral doses of 2360 mg/m2 (400 mg/kg) as well as 5900 mg/m2 (1000 mg/kg), respectively.





Proscar (finasteride), an artificial 4-azasteroid substance, is a specific prevention of steroid Type II 5α-reductase, an intracellular enzyme that transforms the androgen testosterone into 5α-dihydrotestosterone (DHT).

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